Mesenchymal Stem Cells - Interest Group
Directed Differentiation of MSCs towards
Directed differentiation of autologous MSCs towards extra-mesenchymal lineages
is also an interesting area of stem cell biology, with the potential to repair of
tissues where resident stem cells are not accessible, such as the brain. It has
been suggested that MSCs may have the capacity to trans-differentiate into
neuronal cells. However, some members of the research community believe
that experimentation in this area is still inconclusive. Much basic research is
needed in this area, because its mechanisms are not well understood.
Therapeutic applications of MSCs differentiated into extra-mesenchymal lineages
are not likely to occur within the foreseeable future.
Interestingly, in the trailing twelve months, rates of research exploring directed
differentiation of MSCs toward extra-mesenchymal lineages composed less than 5
percent of MSC directed differentiation research, while rates of research
exploring directed differentiation of MSCs toward intra-mesenchymal lineages
consisted of over 95 percent.